In silico examination of peptides containing selenium and ebselen Backbone To Assess Their Tumoricidal Potential

Introduction: Cancer has been one of the highest causes morbidity and mortality in world for decades. Owing to improved therapeutics along with detection, breast cancer slowly reducing. The incidence cancer, on other hand, increased gradually. More than 100 types have identified a wide range treatment protocols comprising chemotherapy, radiation therapy, hormone etc. In an attempt curb serious deleterious effects caused by chemotherapeutic drugs, numerous peptide molecules are currently popular as alternatives standard drugs. Methods: this study, we carried out silico investigations ascertain anti-proliferative potential novel peptides based selenium ebselen, i.e. Eb-Trp-Asp, 13, Eb-Trp-Glu, 14, Eb-Trp-Lys, 15. Analysis protein-ligand interactions, resulting complex formation, using AutoDockVina PyRx aided molecular docking technique, which may be essential indication druggability test peptides. Results: results revealed that screened ligands had extraordinarily strong binding interactions affinity target. Conclusion: Findings suggested molecule 14 potent anticancer agent.